bs-83811C [Life Science]
NVP-2
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Formulation Off-white to beige solid

Storage: -20°C

Product Information:

NVP-2 is a highly selective and potent (IC50 = 0.514 nM) inhibitor of cyclin dependent kinase 9 (CDK9).1 It inhibited proliferation of MOLT4 cells (IC50 = 9 nM). Treatment of cells with NVP-2 resulted in profound downregulation of core regulatory circuitry genes. It has also been shown to be a potent inhibitor of CDK10 (IC50 = 29 nM; this study gives an IC50 of 6 nM for CDK9).2 NVP-2 acted synergistically with orlistat to inhibit acute myeloid leukemia cells (IC50s: Kasumi-1 cells 7.58 nM; U937 cells 8.99 nM).3

Description:

CAS Number: 1263373-43-8<br></br>Chemical Name: 4-[[[6-[5-Chloro-2-[[4-[[(2R)-1-methoxypropan-2-yl]amino]cyclohexyl]amino]pyridin-4-yl]pyridin-2-yl]amino]methyl]oxane-4-carbonitrile<br></br>Molecular Weight: 513.08<br></br>Formula: C27H37ClN6O2<br></br>Solubility: DMSO (>25 mg/ml)<br></br>Physical Properties: Off-white to beige solid<br></br>Purity: >98% by HPLC NMR (Conforms)

Size: 5mg,25mg

Applications: Life Science()

For research use only. Not intended for diagnostic or therapeutic use.