bs-83830C
[Life Science]
MZ1
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support@biossusa.com
800.501.7654 [DOMESTIC]
+1.781.569.5821 [INTERNATIONAL]
DATASHEET
Formulation Pale-yellow solid
Storage: -20°C
Product Information:
MZ1 consists of JQ1 tethered to a ligand for the E3 ubiquitin ligase VHL and is a selective degrader of the BET bromodomain protein BRD4. It rapidly and potently induces reversible, long-lasting and unexpectedly selective degradation of BRD4 over BRD2 and BRD3.1 It exerts anticancer effects in acute myeloid leukemia by targeting c-Myc and ANP32B.2 An important tool for studying the effects of BRD4 degradation in cancer therapy.3
Description:
CAS Number: 1797406-69-9<br></br>Chemical Name: (2S,4R)-1-((S)-2-(tert-Butyl)-17-((S)-4-(4-chlorophenyl)-2,3,9-trimethyl-6H-thieno[3,2-f][1,2,4]triazolo[4,3-a][1,4]diazepin-6-yl)-4,16-dioxo-6,9,12-trioxa-3,15-diazaheptadecan-1-oyl)-4-hydroxy-N-(4-(4-methylthiazol-5-yl)benzyl)pyrrolidine-2-carboxamide<br></br>Molecular Weight: 1002.64<br></br>Formula: C49H60ClN9O8S2<br></br>Solubility: DMSO (100 mg/ml)<br></br>Physical Properties: Pale-yellow solid<br></br>Purity: >98% by HPLC NMR (Conforms)
Size: 1mg, 5mg
Applications: Life Science
For research use only. Not intended for diagnostic or therapeutic use.