bs-8486R-A488 [Conjugated Primary Antibody]
FNDC5 Polyclonal Antibody, ALEXA FLUOR® 488 Conjugated
www.biossusa.com
[email protected]
800.501.7654 [DOMESTIC]
+1.781.569.5821 [INTERNATIONAL]
DATASHEET

Host: Rabbit

Target Protein: FNDC5

Immunogen Range: 81-143/212


Clonality: Polyclonal

Isotype: IgG

Entrez Gene: 252995

Swiss Prot: Q8NAU1

Source: KLH conjugated synthetic peptide derived from human FNDC5 Irisin

Purification: Purified by Protein A.

Storage Buffer: Aqueous buffered solution containing 0.01M TBS (pH 7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.

Storage: Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.

Background:

Irisin: Contrary to mouse, may not be involved in the beneficial effects of muscular exercise, nor in the induction of browning of human white adipose tissue.

Conjugation: ALEXA FLUOR® 488

Excitation/ Emission: 490nm/525nm

Size: 100ul

Concentration: 1ug/ul

Applications: WB(1:300-5000)
IF(IHC-P)(1:50-200)
IF(IHC-F)(1:50-200)
IF(ICC)(1:50-200)

Predicted Molecular Weight: 24


Cross Reactive Species: Human
Mouse
Rat

Predicted Cross Reactive Species: Dog
Chicken
Rabbit

For research use only. Not intended for diagnostic or therapeutic use.

PRODUCT SPECIFIC PUBLICATIONS
  • Park, Min-Jung, et al. "New role of irisin in hepatocytes: The protective effect of hepatic steatosis in vitro." Cellular Signalling (2015).Read more>>
  • Gao et al. Effects and Molecular Mechanism of GST-Irisin on Lipolysis and Autocrine Function in 3T3-L1 Adipocytes. (2016) PLoS.On. 11:e0147480Read more>>
  • Abbasian S et al. The effect of antecedent-conditioning high-intensity interval training on BDNF regulation through PGC-1α pathway following cerebral ischemia. Brain Res. 2020 Feb 15;1729:146618. Read more>>
  • Daniel Norman. et al. Irisin—A Pancreatic Islet Hormone. Biomedicines. 2022 Feb;10(2):258Read more>>
  • Shou-En Wu. et al. Benzo[a]pyrene exposure in muscle triggers sarcopenia through aryl hydrocarbon receptor-mediated reactive oxygen species production. ECOTOX ENVIRON SAFE. 2022 Jul;239:113599Read more>>
  • Guangning Kou. et al. Sesamin Activates Skeletal Muscle FNDC5 Expression and Increases Irisin Secretion via the SIRT1 Signaling Pathway. J AGR FOOD CHEM. 2022;XXXX(XXX):XXX-XXXRead more>>
  • Chen Taiqiu. et al. Irisin Ameliorates Intervertebral Disc Degeneration by Activating LATS/YAP/CTGF Signaling. OXID MED CELL LONGEV. 2022;2022:9684062Read more>>
  • Zhang Lijiao. et al. Dysregulated myokines and signaling pathways in skeletal muscle dysfunction in a cigarette smokeinduced model of chronic obstructive pulmonary disease. FRONT PHYSIOL. 2022 Aug;0:16Read more>>
  • Rui Jiao. et al. Irisin Attenuates Fine Particulate Matter Induced Acute Lung Injury by Regulating Nod2/NF-B Signaling Pathway. IMMUNOBIOLOGY. 2023 Feb;:152358Read more>>
  • Zhuoxiao Han. et al. Irisin attenuates acute lung injury by suppressing the pyroptosis of alveolar macrophages. INT J MOL MED. 2023 Apr;51(4):1-18Read more>>
  • Jiao Ma. et al. Irisin Ameliorates PM2.5-Induced Acute Lung Injury by Regulation of Autophagy Through AMPK/mTOR Pathway. J INFLAMM RES. 2023 Mar 1Read more>>
  • Chuanxi Tang. et al. Treadmill Exercise Alleviates Cognition Disorder by Activating the FNDC5: Dual Role of Integrin αV/β5 in Parkinson’s Disease. INT J MOL SCI. 2023 Jan;24(9):783Read more>>
VALIDATION IMAGES