bs-8520R [Primary Antibody]
MtTF1 Polyclonal Antibody
www.biossusa.com
[email protected]
800.501.7654 [DOMESTIC]
+1.781.569.5821 [INTERNATIONAL]
DATASHEET

Host: Rabbit

Target Protein: MtTF1

Immunogen Range: 155-246/246


Clonality: Polyclonal

Isotype: IgG

Entrez Gene: 7019

Swiss Prot: Q00059

Source: KLH conjugated synthetic peptide derived from human MtTF1

Purification: Purified by Protein A.

Storage Buffer: 0.01M TBS(pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.

Storage: Shipped at 4°C. Store at -20°C for one year. Avoid repeated freeze/thaw cycles.

Background:

Binds to the mitochondrial light strand promoter and functions in mitochondrial transcription regulation. Required for accurate and efficient promoter recognition by the mitochondrial RNA polymerase. Promotes transcription initiation from the HSP1 and the light strand promoter by binding immediately upstream of transcriptional start sites. Is able to unwind DNA. Bends the mitochondrial light strand promoter DNA into a U-turn shape via its HMG boxes. Required for maintenance of normal levels of mitochondrial DNA. May play a role in organizing and compacting mitochondrial DNA.

Size: 100ul

Concentration: 1ug/ul

Applications: WB(1:300-5000)
ELISA(1:500-1000)
IHC-P(1:200-400)
IHC-F(1:100-500)
IF(IHC-P)(1:50-200)
IF(IHC-F)(1:50-200)
IF(ICC)(1:50-200)

Predicted Molecular Weight: 29


Cross Reactive Species: Mouse
Rat

Predicted Cross Reactive Species: Human
Dog
Cow
Sheep
Pig
Rabbit
Goat

For research use only. Not intended for diagnostic or therapeutic use.

PRODUCT SPECIFIC PUBLICATIONS
  • Yan, Wei, et al. "Acute nitrogen dioxide inhalation induces mitochondrial dysfunction in rat brain." Environmental Research 138 (2015): 416-424.Read more>>
  • You, Yan, et al. "Protective Effects of PGC-1α via the Mitochondrial Pathway in Rat Brains after Intracerebral Hemorrhage." Brain Research(2016).Read more>>
  • Yan et al. Deferoxamine ameliorates adipocyte dysfunction by modulating iron metabolism in ob/ob mice. (2018) Endocr.Connect. 7:604-616Read more>>
  • Liu H et al. Cybrid Model Supports Mitochondrial Genetic Effect on Pig Litter SizeFront Genet.2020 Dec 15;11:579382.Read more>>
  • Guangning Kou. et al. Nobiletin activates thermogenesis of brown and white adipose tissue in high\fat diet\fed C57BL/6 mice by shaping the gut microbiota. Faseb J. 2021 Feb;35(2):e21267Read more>>