bs-8565R-A647

DATASHEET

Host: Rabbit

Target Protein: RENT1/hUPF1

Immunogen Range: 301-450/1129

Clonality: Polyclonal

Isotype: IgG

Entrez Gene: 5976

Source: KLH conjugated synthetic peptide derived from human RENT1/hUPF1

Purification: Purified by Protein A.

Storage Buffer: Aqueous buffered solution containing 0.01M TBS (pH 7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.

Storage: Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.

Background:

In eukaryotes, it is essential to have the ability to detect and degrade transcripts that lack full coding potential. Nonsense-mediated RNA decay (NMD) protects the organism by avoiding the translation of truncated peptides with dominant negative or deleterious gain-of-function potential. Rent1, a mammalian ortholog of Upflp, is essential for embryonic viability (13). Rent1 (also designated regulator of nonsense transcripts and HUpf1) contains an N-terminal zinc finger-like domain, NTPase domains and a region comprised of domains that define Rent1 as a superfamily group I helicase.

Conjugation: ALEXA FLUOR® 647

Excitation/ Emission: 650nm/665nm

Size: 100ul

Concentration: 1ug/ul

Applications: IF(IHC-P)(1:50-200)
IF(IHC-F)(1:50-200)
IF(ICC)(1:50-200)

Predicted Molecular Weight: 124

Cross Reactive Species: Others

Predicted Cross Reactive Species: Human
Mouse
Rat
Dog
Cow
Horse
Chicken

For research use only. Not intended for diagnostic or therapeutic use.