bs-8873R [Primary Antibody]
CD36 Polyclonal Antibody
www.biossusa.com
[email protected]
800.501.7654 [DOMESTIC]
+1.781.569.5821 [INTERNATIONAL]
DATASHEET

Host: Rabbit

Target Protein: CD36

Immunogen Range: 351-430/472


Clonality: Polyclonal

Isotype: IgG

Entrez Gene: 948

Swiss Prot: P16671

Source: KLH conjugated synthetic peptide derived from human CD36

Purification: Purified by Protein A.

Storage Buffer: 0.01M TBS(pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.

Storage: Shipped at 4°C. Store at -20°C for one year. Avoid repeated freeze/thaw cycles.

Background:

Binds to collagen, thrombospondin, anionic phospholipids and oxidized low-density lipoprotein (oxLDL). May function as a cell adhesion molecule. Directly mediates cytoadherence of Plasmodium falciparum parasitized erythrocytes. Binds long chain fatty acids and may function in the transport and/or as a regulator of fatty acid transport. Receptor for thombospondins, THBS1 AND THBS2, mediating their antiangiogenic effects. As a coreceptor for TLR4-TLR6 heterodimer, promotes inflammation in monocytes/macrophages. Upon ligand binding, such as oxLDL or amyloid-beta 42, rapidly induces the formation of a heterodimer of TLR4 and TLR6, which is internalized and triggers inflammatory response, leading to NF-kappa-B-dependent production of CXCL1, CXCL2 and CCL9 cytokines, via MYD88 signaling pathway, and CCL5 cytokine, via TICAM1 signaling pathway, as well as IL1B secretion.

Size: 100ul

Concentration: 1ug/ul

Applications: WB(1:300-5000)
IHC-P(1:200-400)
IF(IHC-P)(1:50-200)

Predicted Molecular Weight: 53


Cross Reactive Species: Human
Mouse
Rat

For research use only. Not intended for diagnostic or therapeutic use.

PRODUCT SPECIFIC PUBLICATIONS
  • Weinheimer C et al. Maternal Tobacco Smoke Exposure Causes Sex-Divergent Changes in Placental Lipid Metabolism in the Rat. Reprod Sci. 2020 Jan 6. Read more>>
  • Fang JY et al. Switch of macrophage fusion competency by 3D matrices. Sci Rep. 2020 Jun 25;10(1):10348.Read more>>
  • Yanhong Li. et al. Therapeutic potential of human umbilical cord mesenchymal stem cells on aortic atherosclerotic plaque in a high-fat diet rabbit model. Stem Cell Res Ther. 2021 Dec;12(1):1-14Read more>>
  • Xiaohui Xu. et al. Hexafluoropropylene oxide dimer acid (HFPO-DA) induced developmental cardiotoxicity and hepatotoxicity in hatchling chickens: Roles of peroxisome proliferator activated receptor alpha. Environ Pollut. 2021 Dec;290:118112Read more>>
  • Dashdulam Davaanyam. et al. Intranasal Delivery of RGD-Containing Osteopontin Heptamer Peptide Confers Neuroprotection in the Ischemic Brain and Augments Microglia M2 Polarization. Int J Mol Sci. 2021 Jan;22(18):9999Read more>>
  • Ziyi Pan. et al. A Novel in Duck Myoblasts: The Transcription Factor Retinoid X Receptor Alpha (RXRA) Inhibits Lipid Accumulation by Promoting CD36 Expression. INT J MOL SCI. 2023 Jan;24(2):118Read more>>
  • Yanhong Li. et al. Allogeneic Adipose-Derived Mesenchymal Stem Cell Transplantation Alleviates Atherosclerotic Plaque by Inhibiting Ox-LDL Uptake, Inflammatory Reaction and Endothelial Damage in Rabbits. CELLS-BASEL. 2023 Jan;12(15):1936Read more>>
  • Qicai Liu. et al. Adropin deficiency worsens TNBS-induced colitis. INT IMMUNOPHARMACOL. 2023 Nov;124:110891Read more>>
  • Miao Zhang. et al. The Different Mechanisms of Lipid Accumulation in Hepatocytes Induced by Oleic Acid/Palmitic Acid and High-Fat Diet. MOLECULES. 2023 Jan;28(18):6714Read more>>
VALIDATION IMAGES

Formalin-fixed and paraffin embedded mouse spleen labeled with Rabbit Anti CD36/PAS-4 Polyclonal Antibody, Unconjugated (bs-8873R) at 1:200 followed by conjugation to the secondary antibody and DAB staining


L1 mouse intestine lysates L2 rat lung lysates probed with Anti CD36/PAS-4 Polyclonal Antibody, Unconjugated (bs-8873R) at 1:200 overnight at 4˚C. Followed by conjugation to secondary antibody (bs-0295G-HRP) at 1:3000 for 90 min at RT. Predicted band 5kD. Observed band size:41kD.\n