bsm-30217M-APC

DATASHEET

Host: Mouse

Target Protein: Tumor necrosis factor receptor superfamily member 13C

Clonality: Monoclonal

Isotype: IgG2a/Kappa

Entrez Gene: 115650

Swiss Prot: Q96RJ3

Purification: Affinity purified by Protein G

Storage Buffer: 0.01M PBS, 0.5%BSA, 0.02% Proclin300

Storage: Store at 2-8°C

Background:

B cell-activating factor (BAFF) enhances B-cell survival in vitro and is a regulator of the peripheral B-cell population. Overexpression of Baff in mice results in mature B-cell hyperplasia and symptoms of systemic lupus erythematosus (SLE). Also, some SLE patients have increased levels of BAFF in serum. Therefore, it has been proposed that abnormally high levels of BAFF may contribute to the pathogenesis of autoimmune diseases by enhancing the survival of autoreactive B cells. The protein encoded by this gene is a receptor for BAFF and is a type III transmembrane protein containing a single extracellular cysteine-rich domain. It is thought that this receptor is the principal receptor required for BAFF-mediated mature B-cell survival. [provided by RefSeq, Jul 2008]

Size: 25T, 100T

Concentration: n/a

Applications: FCM(10ul/10^6 cells in 100ul)

Predicted Molecular Weight: 19

Cross Reactive Species: Human

For research use only. Not intended for diagnostic or therapeutic use.