bsm-34042M-PerCP-Cy5.5

DATASHEET

Host: Mouse

Target Protein: LMNA | Lamin A/C

Clonality: Monoclonal

Isotype: IgG

Entrez Gene: 4000

Swiss Prot: P02545

Source: KLH conjugated synthetic peptide derived from human lamin A

Purification: purified by Protein A.

Storage Buffer: Aqueous buffered solution containing 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.

Storage: Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.

Background:

The nuclear lamina consists of a two-dimensional matrix of proteins located next to the inner nuclear membrane. The lamin family of proteins make up the matrix and are highly conserved in evolution. During mitosis, the lamina matrix is reversibly disassembled as the lamin proteins are phosphorylated. Lamin proteins are thought to be involved in nuclear stability, chromatin structure and gene expression. Vertebrate lamins consist of two types, A and B. Alternative splicing results in multiple transcript variants. Mutations in this gene lead to several diseases: Emery-Dreifuss muscular dystrophy, familial partial lipodystrophy, limb girdle muscular dystrophy, dilated cardiomyopathy, Charcot-Marie-Tooth disease, and Hutchinson-Gilford progeria syndrome. [provided by RefSeq, Apr 2012]

Conjugation: PerCP-Cy5.5

Excitation/ Emission: 482nm/694nm

Size: 100ul

Concentration: 1mg/ml

Applications: WB(1:1000-2000)
ELISA(1:5000-10000)
IHC-F(1:100-500)
IF(1:100-500)
IHC-P(1:100-500)
ICC/IF(1:100-200)

Predicted Molecular Weight: 69/62 kDa

Cross Reactive Species: Human
Mouse
Rat

Predicted Cross Reactive Species: Dog
Cow
Horse
Pig

For research use only. Not intended for diagnostic or therapeutic use.