bsm-41519R

DATASHEET

Host: Rabbit

Target Protein: SARS-CoV-2 (2019-nCoV) Nucleocapsid

Clonality: Monoclonal

Isotype: IgG1

Entrez Gene: 43740575

Swiss Prot: P0DTC9

Source: Recombinant SARS-CoV-2 Nucleocapsid Protein

Purification: affinity purified by Protein A

Storage Buffer: 0.01M TBS(pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.

Storage: Shipped at 4C. Store at -20C for one year. Avoid repeated freeze/thaw cycles.

Background:

Coronaviruses are enveloped viruses with a positive-sense RNA genome and with a nucleocapsid of helical symmetry. Coronavirus nucleoproteins localize to the cytoplasm and the nucleolus, a subnuclear structure, in both virus-infected primary cells and in cells transfected with plasmids that express N protein. Coronavirus N protein is required for coronavirus RNA synthesis, and has RNA chaperone activity that may be involved in template switch. Nucleocapsid protein is a most abundant protein of coronavirus. During virion assembly, N protein binds to viral RNA and leads to formation of the helical nucleocapsid. Nucleocapsid protein is a highly immunogenic phosphoprotein also implicated in viral genome replication and in modulating cell signaling pathways. Because of the conservation of N protein sequence and its strong immunogenicity, the N protein of coronavirus is chosen as a diagnostic tool.

Size: 100µL

Concentration: 1mg/ml

Applications: ELISA(1:500-1000)

Predicted Molecular Weight: 46

Cross Reactive Species: SARS-CoV-2

For research use only. Not intended for diagnostic or therapeutic use.