bsm-41722M-BF488

DATASHEET

Host: Mouse

Target Protein: Tau

Immunogen Range: 1-441/441

Clonality: Monoclonal

Isotype: IgG

Entrez Gene: 4137

Swiss Prot: P10636-8

Source: Recombinant Human Tau-4 Protein

Purification: Purified by Protein A.

Storage Buffer: Aqueous buffered solution containing 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.

Storage: Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.

Background:

Tau proteins are important Promotes microtubule assembly and stability, and might be involved in the establishment and maintenance of neuronal polarity. The C-terminus binds axonal microtubules while the N-terminus binds neural plasma membrane components, suggesting that tau functions as a linker protein between both. Axonal polarity is predetermined by tau localization (in the neuronal cell) in the domain of the cell body defined by the centrosome. The short isoforms allow plasticity of the cytoskeleton whereas the longer isoforms may preferentially play a role in its stabilization. Tau proteins subcellular located in the axons of neurons, in the cytoso l and in association with plasma membrane components. It expressed in neurons. PNS-tau is expressed in the peripheral nervous system while the others are expressed in the central nervous system.

Conjugation: AbBy Fluor-488

Excitation/ Emission: 499nm/519nm

Size: 100µL

Concentration: 1ug/ul

Applications: WB(WB(1:500-2000))
IF(IHC-P)(IF(IHC-P)(1:100-500))

Predicted Molecular Weight: 46/79

Cross Reactive Species: Human

For research use only. Not intended for diagnostic or therapeutic use.