bsm-51071M

DATASHEET

Host: Mouse

Target Protein: MASTL

Clonality: Monoclonal

Isotype: IgG1

Entrez Gene: 84930

Swiss Prot: Q96GX5

Source: This MASTL monoclonal antibody is generated from mouse immunized with MASTL recombinant protein.

Purification: Mouse monoclonal antibody supplied in crude ascites with 0.09% (W/V) sodium azide.

Storage Buffer: 0.01M TBS(pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.

Storage: Store at -20°C for 12 months.

Background:

Serine/threonine kinase that plays a key role in M phase by acting as a regulator of mitosis entry and maintenance. Acts by promoting the inactivation of protein phosphatase 2A (PP2A) during M phase: does not directly inhibit PP2A but acts by mediating phosphorylation and subsequent activation of ARPP19 and ENSA at 'Ser-62' and 'Ser-67', respectively. ARPP19 and ENSA are phosphatase inhibitors that specifically inhibit the PPP2R2D (PR55-delta) subunit of PP2A. Inactivation of PP2A during M phase is essential to keep cyclin-B1-CDK1 activity high. Following DNA damage, it is also involved in checkpoint recovery by being inhibited. Phosphorylates histone protein in vitro; however such activity is unsure in vivo. May be involved in megakaryocyte differentiation.

Size: 100µL

Concentration: 0.5ug/ul

Predicted Molecular Weight: 97

Cross Reactive Species: Human

For research use only. Not intended for diagnostic or therapeutic use.