bsm-51126M [Primary Antibody]
MUC1 (M5C7) Monoclonal Antibody
www.biossusa.com
[email protected]
800.501.7654 [DOMESTIC]
+1.781.569.5821 [INTERNATIONAL]
DATASHEET

Host: Mouse

Target Protein: MUC1

Clonality: Monoclonal

Isotype: IgG2b

Entrez Gene: 4582

Swiss Prot: P15941

Source: Purified His-tagged MUC1 protein(Fragment) was used to produced this monoclonal antibody.

Purification: Purified monoclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is prepared by Saturated Ammonium Sulfate (SAS) precipitation followed by dialysis against PBS.

Storage Buffer: 0.01M TBS(pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.

Storage: Shipped at 4°C. Store at -20°C for one year. Avoid repeated freeze/thaw cycles.

Background:

The alpha subunit has cell adhesive properties. Can act both as an adhesion and an anti-adhesion protein. May provide a protective layer on epithelial cells against bacterial and enzyme attack. The beta subunit contains a C-terminal domain which is involved in cell signaling, through phosphorylations and protein-protein interactions. Modulates signaling in ERK, SRC and NF-kappa-B pathways. In activated T-cells, influences directly or indirectly the Ras/MAPK pathway. Promotes tumor progression. Regulates TP53-mediated transcription and determines cell fate in the genotoxic stress response. Binds, together with KLF4, the PE21 promoter element of TP53 and represses TP53 activity.

Size: 100ul

Concentration: 0.5ug/ul

Predicted Molecular Weight: 122


Cross Reactive Species: Human
Mouse

For research use only. Not intended for diagnostic or therapeutic use.

PRODUCT SPECIFIC PUBLICATIONS
  • Sun, Y et al.Modified apple polysaccharide influences MUC-1 expression to prevent ICR mice from colitis-associated carcinogenesis.Int. J. Biol. Macromol. 2018 Sep 25 ;120(Pt B)Read more>>
  • Zhao Ting. et al. Berberine Inhibits the Adhesion of Candida albicans to Vaginal Epithelial Cells. Front Pharmacol. 2022 Feb;0:511Read more>>
  • Wang Ruibiao. et al. Effects of exosomes derived from Trichinella spiralis infective larvae on intestinal epithelial barrier function. VET RES. 2022 Dec;53(1):1-11Read more>>
VALIDATION IMAGES

Lane 1: MDA-MB435 Cells; 35ug loaded into the lane; Probed with MUC1 (M5C7) Monoclonal Antibody, Unconjugated (bsm-51126M) at 1:200 overnight at 4°C followed by a conjugated secondary antibody for 60 minutes at 37°C.