bsm-51147M

DATASHEET

Host: Mouse

Target Protein: DDR2

Immunogen Range: 290-320/855

Clonality: Monoclonal

Isotype: IgG1

Entrez Gene: 4921

Swiss Prot: Q16832

Source: This DDR2 antibody is generated from mice immunized with a KLH conjugated synthetic peptide between 290-320 amino acids from human DDR2.

Purification: Mouse monoclonal antibody supplied in crude ascites with 0.09% (W/V) sodium azide.

Storage Buffer: 0.01M TBS(pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.

Storage: Shipped at 4°C. Store at -20°C for one year. Avoid repeated freeze/thaw cycles.

Background:

Tyrosine kinase that functions as cell surface receptor for fibrillar collagen and regulates cell differentiation, remodeling of the extracellular matrix, cell migration and cell proliferation. Required for normal bone development. Regulates osteoblast differentiation and chondrocyte maturation via a signaling pathway that involves MAP kinases and leads to the activation of the transcription factor RUNX2. Regulates remodeling of the extracellular matrix by up-regulation of the collagenases MMP1, MMP2 and MMP13, and thereby facilitates cell migration and tumor cell invasion. Promotes fibroblast migration and proliferation, and thereby contributes to cutaneous wound healing.

Size: 100ul

Concentration: 0.5ug/ul

Predicted Molecular Weight: 97

Cross Reactive Species: Human

For research use only. Not intended for diagnostic or therapeutic use.