bsm-51241M

DATASHEET

Host: Mouse

Target Protein: SUMO2

Clonality: Monoclonal

Isotype: IgG2b

Entrez Gene: 6613

Swiss Prot: P61956

Source: Purified His-tagged SUMO2 protein was used to produced this monoclonal antibody.

Purification: Purified monoclonal antibody supplied in PBS with 0.09% (W/V) sodium azide. This antibody is purifie

Storage Buffer: 0.01M TBS(pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.

Storage: Store at -20°C for 12 months.

Background:

Ubiquitin-like protein that can be covalently attached to proteins as a monomer or as a lysine-linked polymer. Covalent attachment via an isopeptide bond to its substrates requires prior activation by the E1 complex SAE1-SAE2 and linkage to the E2 enzyme UBE2I, and can be promoted by an E3 ligase such as PIAS1-4, RANBP2, CBX4 or ZNF451 (PubMed:26524494). This post-translational modification on lysine residues of proteins plays a crucial role in a number of cellular processes such as nuclear transport, DNA replication and repair, mitosis and signal transduction. Polymeric SUMO2 chains are also susceptible to polyubiquitination which functions as a signal for proteasomal degradation of modified proteins (PubMed:18408734, PubMed:18538659, PubMed:21965678, PubMed:9556629). Plays a role in the regulation of sumoylation status of SETX (PubMed:24105744).

Size: 100uL

Concentration: 0.5ug/ul

Applications: WB(1:300-5000)
IF(ICC)(1:50-200)
IF(1:50-200)

Predicted Molecular Weight: 11

Cross Reactive Species: Human
Rat

For research use only. Not intended for diagnostic or therapeutic use.