bsm-51265M [Primary Antibody]
PINK1 (8T5) Monoclonal Antibody
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Host: Mouse

Target Protein: PINK1

Clonality: Monoclonal

Isotype: IgG1

Entrez Gene: 65018

Swiss Prot: Q9BXM7

Source: Recombinant PINK1 protein was used to produced this monoclonal antibody.

Purification: Purified by Protein G.

Storage Buffer: 0.01M TBS(pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.

Storage: Shipped at 4C. Store at -20C for one year. Avoid repeated freeze/thaw cycles.

Background:

Protects against mitochondrial dysfunction during cellular stress by phosphorylating mitochondrial proteins. Involved in the clearance of damaged mitochondria via selective autophagy (mitophagy) by mediating activation and translocation of PARK2. Targets PARK2 to dysfunctional depolarized mitochondria through the phosphorylation of MFN2. Activates PARK2 in 2 steps: (1) by mediating phosphorylation at 'Ser-65' of PARK2 and (2) mediating phosphorylation of ubiquitin, converting PARK2 to its fully-active form (PubMed:24660806, PubMed:24751536, PubMed:24784582, PubMed:25527291).

Size: 100ul

Concentration: Lot Dependent

Applications: WB(1:200-1000)
IHC-F(1:100-500)
IF(1:20-200)
IHC-P(1:100-500)
ICC/IF(1:50-100)

Predicted Molecular Weight: 63


Cross Reactive Species: Human

For research use only. Not intended for diagnostic or therapeutic use.

PRODUCT SPECIFIC PUBLICATIONS
  • Yajing Wang. et al. Long-term exposure to the fluoride blocks the development of chondrocytes in the ducks: The molecular mechanism of fluoride regulating autophagy and apoptosis. Ecotox Environ Safe. 2021 Jul;217:112225Read more>>
  • Xuliang Zhang. et al. PINK1/Parkin-mediated mitophagy mitigates T-2 toxin-induced nephrotoxicity. FOOD CHEM TOXICOL. 2022 Jun;164:113078Read more>>
  • Zhang, Kai. et al. Long-Term Copper Exposure Induced Excessive Autophagy of the Porcine Spleen. BIOL TRACE ELEM RES. 2022 Jul;:1-9Read more>>
  • Chuanling Wang. et al. Berberine Rescues D-Ribose-Induced Alzheimer‘s Pathology via Promoting Mitophagy. INT J MOL SCI. 2023 Jan;24(6):5896Read more>>