bsm-51292M

DATASHEET

Host: Mouse

Target Protein: ATG4A

Clonality: Monoclonal

Isotype: IgG2b

Entrez Gene: 115201

Swiss Prot: Q8WYN0

Source: This ATG4A antibody is generated from a mouse immunized with a recombinant protein.

Purification: Purified by Protein G.

Storage Buffer: 0.01M TBS(pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.

Storage: Store at -20°C for 12 months.

Background:

Cysteine protease required for the cytoplasm to vacuole transport (Cvt) and autophagy. Cleaves the C-terminal amino acid of ATG8 family proteins to reveal a C-terminal glycine. Exposure of the glycine at the C-terminus is essential for ATG8 proteins conjugation to phosphatidylethanolamine (PE) and insertion to membranes, which is necessary for autophagy. Preferred substrate is GABARAPL2 followed by MAP1LC3A and GABARAP. Has also an activity of delipidating enzyme for the PE-conjugated forms.

Size: 100ul

Concentration: Lot Dependent

Applications: WB(1:300-5000)
IF(ICC)(1:50-200)
IF(1:50-200)
IHC-P(1:200-400)

Predicted Molecular Weight: 45

Cross Reactive Species: Human

For research use only. Not intended for diagnostic or therapeutic use.