bsm-51457M

DATASHEET

Host: Mouse

Target Protein: SUMO1

Clonality: Monoclonal

Isotype: IgG1

Entrez Gene: 7341

Swiss Prot: P63165

Source: Recombinant GST fusion protein encoding human SUMO1.

Storage Buffer: 0.01M TBS(pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.

Storage: Shipped at 4℃. Store at -20℃ for one year. Avoid repeated freeze/thaw cycles.

Background:

Ubiquitin-like protein that can be covalently attached to proteins as a monomer or a lysine-linked polymer. Covalent attachment via an isopeptide bond to its substrates requires prior activation by the E1 complex SAE1-SAE2 and linkage to the E2 enzyme UBE2I, and can be promoted by E3 ligases such as PIAS1-4, RANBP2 or CBX4. This post-translational modification on lysine residues of proteins plays a crucial role in a number of cellular processes such as nuclear transport, DNA replication and repair, mitosis and signal transduction. Involved for instance in targeting RANGAP1 to the nuclear pore complex protein RANBP2. Polymeric SUMO1 chains are also susceptible to polyubiquitination which functions as a signal for proteasomal degradation of modified proteins. May also regulate a network of genes involved in palate development.

Size: 100µL

Concentration: 0.5ug/ul

Applications: WB(WB=1:500-1000)

Predicted Molecular Weight: 12

Cross Reactive Species: Human

For research use only. Not intended for diagnostic or therapeutic use.