bsm-51547M [Primary Antibody]
EPHB4 Monoclonal Antibody
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Host: Mouse

Target Protein: EPHB4

Clonality: Monoclonal

Entrez Gene: 2050

Swiss Prot: P54760

Source: Recombinant human EPHB4.

Storage Buffer: 0.01M TBS(pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.

Storage: Shipped at 4℃. Store at -20℃ for one year. Avoid repeated freeze/thaw cycles.

Background:

Receptor tyrosine kinase which binds promiscuously transmembrane ephrin-B family ligands residing on adjacent cells, leading to contact-dependent bidirectional signaling into neighboring cells. The signaling pathway downstream of the receptor is referred to as forward signaling while the signaling pathway downstream of the ephrin ligand is referred to as reverse signaling. Together with its cognate ligand/functional ligand EFNB2 plays a central role in heart morphogenesis and angiogenesis through regulation of cell adhesion and cell migration. EPHB4-mediated forward signaling controls cellular repulsion and segregation form EFNB2-expressing cells. Plays also a role in postnatal blood vessel remodeling, morphogenesis and permeability and is thus important in the context of tumor angiogenesis.

Size: 100µL

Concentration: 0.5ug/ul

Applications: WB(WB=1:200-2000)

Predicted Molecular Weight: 107


Cross Reactive Species: Recombinant protein

Predicted Cross Reactive Species: Human

For research use only. Not intended for diagnostic or therapeutic use.

VALIDATION IMAGES

Lane 1: EPHB4 recombinant protein probed with EPHB4 Monoclonal Antibody, Unconjugated (bsm-51547M) at 1:1000 dilution and 4°C overnight incubation. Followed by conjugated secondary antibody incubation at 1:20000 for 60 min at 37˚C.