bsm-51587M

DATASHEET

Host: Mouse

Target Protein: SP1

Clonality: Monoclonal

Entrez Gene: 6667

Swiss Prot: P08047

Source: Recombinant human SP1.

Storage Buffer: 0.01M TBS(pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.

Storage: Shipped at 4℃. Store at -20℃ for one year. Avoid repeated freeze/thaw cycles.

Background:

Transcription factor that can activate or repress transcription in response to physiological and pathological stimuli. Binds with high affinity to GC-rich motifs and regulates the expression of a large number of genes involved in a variety of processes such as cell growth, apoptosis, differentiation and immune responses. Highly regulated by post-translational modifications (phosphorylations, sumoylation, proteolytic cleavage, glycosylation and acetylation). Binds also the PDGFR-alpha G-box promoter. May have a role in modulating the cellular response to DNA damage. Implicated in chromatin remodeling. Plays a role in the recruitment of SMARCA4/BRG1 on the c-FOS promoter. Plays an essential role in the regulation of FE65 gene expression. In complex with ATF7IP, maintains telomerase activity in cancer cells by inducing TERT and TERC gene expression.

Size: 100ul

Concentration: Lot Dependent

Applications: WB(WB=1:500-1000)
IHC-F(IHC-F=1:100-500)
IF(IF=1:100-500)
Flow-Cyt(Flow-Cyt=1:25)
IHC-P(IHC-P=1:100-500)
ICC/IF(ICC/IF=1:100-500)

Predicted Molecular Weight: 81

Predicted Cross Reactive Species: Human

For research use only. Not intended for diagnostic or therapeutic use.