DATASHEET
Host:
Mouse
Target Protein:
TERF2IP
Clonality:
Monoclonal
Entrez Gene:
54386
Swiss Prot:
Q9NYB0
Source:
Recombinant human TE2IP between 1-399 amino acids.
Storage Buffer:
0.01M TBS(pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.
Storage:
Shipped at 4℃. Store at -20℃ for one year. Avoid repeated freeze/thaw cycles.
Background:
Acts both as a regulator of telomere function and as a transcription regulator. Involved in the regulation of telomere length and protection as a component of the shelterin complex (telosome). In contrast to other components of the shelterin complex, it is dispensible for telomere capping and does not participate in the protection of telomeres against non-homologous end-joining (NHEJ)-mediated repair. Instead, it is required to negatively regulate telomere recombination and is essential for repressing homology-directed repair (HDR), which can affect telomere length. Does not bind DNA directly: recruited to telomeric double-stranded 5'-TTAGGG-3' repeats via its interaction with TERF2. Independently of its function in telomeres, also acts as a transcription regulator: recruited to extratelomeric 5'-TTAGGG-3' sites via its association with TERF2 or other factors, and regulates gene expression. When cytoplasmic, associates with the I-kappa-B-kinase (IKK) complex and acts as a regulator of the NF-kappa-B signaling by promoting IKK-mediated phosphorylation of RELA/p65, leading to activate expression of NF-kappa-B target genes.
Size:
100ul
Concentration:
Lot Dependent
Applications:
WB(WB=1:500-2000)
IHC-F(IHC-F=1:25)
IF(IF=1:25)
IHC-P(IHC-P=1:25)
44
Predicted Cross Reactive Species:
Human
For research use only. Not intended for diagnostic or therapeutic use.