bsm-51662M-Biotin

DATASHEET

Host: Mouse

Target Protein: MDM2

Clonality: Monoclonal

Entrez Gene: 4193

Swiss Prot: Q00987

Source: Recombinant human MDM2 between 196-435 amino acids.

Storage Buffer: Aqueous buffered solution containing 0.01M TBS (pH 7.4) with 1% BSA, 0.03% Proclin300 and 50% Glycerol.

Storage: Store at -20°C for 12 months.

Background:

E3 ubiquitin-protein ligase that mediates ubiquitination of p53/TP53, leading to its degradation by the proteasome. Inhibits p53/TP53- and p73/TP73-mediated cell cycle arrest and apoptosis by binding its transcriptional activation domain. Also acts as an ubiquitin ligase E3 toward itself and ARRB1. Permits the nuclear export of p53/TP53. Promotes proteasome-dependent ubiquitin-independent degradation of retinoblastoma RB1 protein. Inhibits DAXX-mediated apoptosis by inducing its ubiquitination and degradation. Component of the TRIM28/KAP1-MDM2-p53/TP53 complex involved in stabilizing p53/TP53. Also component of the TRIM28/KAP1-ERBB4-MDM2 complex which links growth factor and DNA damage response pathways.

Conjugation: Biotin

Excitation/ Emission: N/A

Size: 100ul

Concentration: 0.5ug/ul

Applications: WB(WB=1:500-2000Ôºå)

Predicted Molecular Weight: 55

Predicted Cross Reactive Species: Human

For research use only. Not intended for diagnostic or therapeutic use.