bsm-51671M-HRP

DATASHEET

Host: Mouse

Target Protein: MBD2

Clonality: Monoclonal

Entrez Gene: 8932

Swiss Prot: Q9UBB5

Source: Recombinant human MBD2 between 10-228 amino acids.

Storage Buffer: Aqueous buffered solution containing 0.01M TBS (pH 7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.

Storage: Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.

Background:

Binds CpG islands in promoters where the DNA is methylated at position 5 of cytosine within CpG dinucleotides. Binds hemimethylated DNA as well. Recruits histone deacetylases and DNA methyltransferases. Acts as transcriptional repressor and plays a role in gene silencing. Functions as a scaffold protein, targeting GATAD2A and GATAD2B to chromatin to promote repression. May enhance the activation of some unmethylated cAMP-responsive promoters.

Conjugation: HRP

Excitation/ Emission: N/A

Size: 100ul

Concentration: 0.5ug/ul

Applications: WB(WB=1:500-4000)
IHC-P(IHC-P=1:25)
IHC-F(IHC-F=1:25)

Predicted Molecular Weight: 43

Predicted Cross Reactive Species: Human

For research use only. Not intended for diagnostic or therapeutic use.