bsm-51675M

DATASHEET

Host: Mouse

Target Protein: HIF1AN

Immunogen Range: 1-349/349

Clonality: Monoclonal

Entrez Gene: 55662

Swiss Prot: Q9NWT6

Source: KLH conjugated synthetic peptide derived from human HIF1AN

Storage Buffer: 0.01M TBS(pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.

Storage: Shipped at 4°C. Store at -20°C for one year. Avoid repeated freeze/thaw cycles.

Background:

Hydroxylates HIF-1 alpha at 'Asp-803' in the C-terminaltransactivation domain (CAD). Functions as an oxygen sensor and,under normoxic conditions, the hydroxylation prevents interactionof HIF-1 with transcriptional coactivators includingCbp/p300-interacting transactivator. Involved in transcriptionalrepression through interaction with HIF1A, VHL and histonedeacetylases. Hydroxylates specific Asn residues within ankyrinrepeat domains (ARD) of NFKB1, NFKBIA, NOTCH1, ASB4, PPP1R12A andseveral other ARD-containing proteins. Also hydroxylates Asp andHis residues within ARDs of ANK1 and TNKS2, respectively.Negatively regulates NOTCH1 activity, accelerating myogenicdifferentiation. Positively regulates ASB4 activity, promotingvascular differentiation.

Size: 100ul

Concentration: 0.5ug/ul

Applications: WB=1:500-4000√î¬∫√•ICC=1:25√î¬∫√•IF=1:25√î¬∫√•

Predicted Molecular Weight: 38

Predicted Cross Reactive Species: Human

For research use only. Not intended for diagnostic or therapeutic use.