Target Protein: 4-Oct
Entrez Gene: 5460
Swiss Prot: Q01860
Source: Synthetic peptide derived from human Oct 4, around 1-50aa.
Purification: Purified by Protein A.
Storage Buffer: Aqueous buffered solution containing 1xTBS (pH7.4), 1%BSA, 40%Glycerol and 0.05% Sodium Azide.
Storage Condition: Store at -20°C for 12 months..
Background: Expression of the POU-domain transcription factor Octamer-4 (Oct-4) is widely regarded as a hallmark of pluripotent stem cells. The relationship of Oct-4 to pluripotent stem cells is indicated by its tightly restricted expression to undifferentiated pluripotent stem cells. Upon differentiation to somatic lineages, the expression of Oct-4 disappears rapidly. Unlike the majority of pluripotent stem cell markers, the biological role of Oct-4 has been well characterized. Studies performed in mice point to the critical role of Oct-4 in the establishment and/or maintenance of pluripotent stem cells in an uncommitted state.
Cross Reactive Species: Human
For research use only. Not intended for diagnostic or therapeutic use.