bsm-52005R-Biotin

DATASHEET

Host: Rabbit

Target Protein: 14-3-3 sigma

Clonality: Monoclonal

Isotype: IgG

Entrez Gene: 2810

Swiss Prot: P31947

Source: Recombinant human 14-3-3 sigma protein, full length.

Purification: Purified by Protein A.

Storage Buffer: Aqueous buffered solution containing 0.01M TBS (pH 7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.

Storage: Store at -20°C for 12 months.

Background:

Adapter protein implicated in the regulation of a large spectrum of both general and specialized signaling pathways. Binds to a large number of partners, usually by recognition of a phosphoserine or phosphothreonine motif. Binding generally results in the modulation of the activity of the binding partner. When bound to KRT17, regulates protein synthesis and epithelial cell growth by stimulating Akt/mTOR pathway. May also regulate MDM2 autoubiquitination and degradation and thereby activate p53/TP53.1 Publication p53-regulated inhibitor of G2/M progression.

Conjugation: Biotin

Excitation/ Emission: N/A

Size: 100µL

Concentration: Lot Dependent

Applications: IHC-P(1:300-5000)
IHC-F(1:100-500)

Cross Reactive Species: Human
Mouse
Rat

For research use only. Not intended for diagnostic or therapeutic use.