bsm-52048R-BF350

DATASHEET

Host: Rabbit

Target Protein: Cyclin E1

Clonality: Recombinant

Isotype: IgG

Entrez Gene: 898

Swiss Prot: P24864

Source: Synthetic peptide derive from human cyclin e1

Purification: Purified by Protein A.

Storage Buffer: Aqueous buffered solution containing 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.

Storage: Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.

Background:

Cyclin E is a regulatory subunit of Cdk2 and controls G1 / S transition during the mammalian cell cycle. Multiple isoforms of Cyclin E are only expressed in tumors but not in normal tissue, suggesting a post transcriptional regulation of Cyclin E. In vitro analyses indicated that these truncated variant isoforms of Cyclin E are able to phosphorylate histone H1. Alterations in the Cyclin E protein have been implicated as indicators of worse prognosis in various cancers.

Conjugation: AbBy Fluor-350

Excitation/ Emission: 346nm/442nm

Size: 100µL

Concentration: Lot dependent

Applications: WB(1:1000-5000)
IF(1:200-500)

Cross Reactive Species: Human

For research use only. Not intended for diagnostic or therapeutic use.