bsm-52062R-HRP

DATASHEET

Host: Rabbit

Target Protein: Cytokeratin 4

Clonality: Recombinant

Isotype: IgG

Entrez Gene: 3851

Swiss Prot: P19013

Source: Recombinant human Cytokeratin 4 protein, around 350-480aa.

Purification: Purified by Protein A.

Storage Buffer: Aqueous buffered solution containing 0.01M TBS (pH 7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.

Storage: Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.

Background:

Defects in KRT4 are a cause of white sponge nevus of cannon (WSN) [MIM:193900]. WSN is a rare autosomal dominant disorder which predominantly affects non-cornified stratified squamous epithelia. Clinically, it is characterized by the presence of soft, white, and spongy plaques in the oral mucosa. The characteristic histopathologic features are epithelial thickening, parakeratosis, and vacuolization of the suprabasal layer of oral epithelial keratinocytes. Less frequently the mucous membranes of the nose, esophagus, genitalia and rectum are involved.

Conjugation: HRP

Excitation/ Emission: N/A

Size: 100ul

Concentration: Lot Dependent

Applications: WB(1:300-5000)

Cross Reactive Species: Rat

Predicted Cross Reactive Species: Human

For research use only. Not intended for diagnostic or therapeutic use.