bsm-52088R-BF594

DATASHEET

Host: Rabbit

Target Protein: HDAC8

Clonality: Recombinant

Isotype: IgG

Entrez Gene: 55869

Swiss Prot: Q9BY41

Source: Recombinant human HDAC8 protein, around N-terminal 150aa.

Purification: Purified by Protein A.

Storage Buffer: Aqueous buffered solution containing 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.

Storage: Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.

Background:

Responsible for the deacetylation of lysine residues on the N-terminal part of the core histones (H2A, H2B, H3 and H4). Histone deacetylation gives a tag for epigenetic repression and plays an important role in transcriptional regulation, cell cycle progression and developmental events. Histone deacetylases act via the formation of large multiprotein complexes. Also involved in the deacetylation of cohesin complex protein SMC3 regulating release of cohesin complexes from chromatin. May play a role in smooth muscle cell contractility.

Conjugation: AbBy Fluor-594

Excitation/ Emission: 590nm/617nm

Size: 100ul

Concentration: Lot dependent

Applications: WB(1:300-5000)
Flow-Cyt(1ug/Test)

Cross Reactive Species: Human

For research use only. Not intended for diagnostic or therapeutic use.