bsm-52159R-PE-Cy7

DATASHEET

Host: Rabbit

Target Protein: Phospho-Glycogen synthase 1 (Ser641)

Modification Site: S641

Clonality: Recombinant

Isotype: IgG

Entrez Gene: 2997

Swiss Prot: P13807

Source: Synthetic peptide derived from human Glycogen synthase 1(S641), around 630-680aa (phospho S641).

Purification: Purified by Protein A.

Storage Buffer: Aqueous buffered solution containing 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.

Storage: Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.

Background:

Glycogen Synthase (GS) is a key enzyme in the regulation of glycogen metabolism. GS catalyzes the incorporation of UDP-glucose incorporation into glycogen. The activity of glycogen synthase is regulated by hormonal stimuli (insulin, catecholamines and glucagons) and non-hormonal stimuli (blood glucose level and exercise). Two main isoforms of mammalian GS are designated as muscle (glycogen synthase 1) and liver (glycogen synthase 2). Most tissues express glycogen synthase 1, whereas glycogen synthase 2 appears to be tissue-specific. The two isoforms have 70% identical amino acid sequence. Glycogen synthase can be phosphorylated by multiple kinases including glycogen synthase kinase-3 (GSK-3), mitogen-activated protein kinase-related protein kinase (DYRK), and SAPK2b/p38b which leads to its inactivation.

Conjugation: PE-Cy7

Excitation/ Emission: 488nm/780nm

Size: 100µL

Concentration: 1mg/ml

Applications: WB(1:20-50)
IHC-P(1:100-500)
IHC-F(1:100-500)
IP(1:50-100)
IF(1:100-500)
Flow-Cyt(1:500-2000)

Cross Reactive Species: Human
Mouse
Rat

For research use only. Not intended for diagnostic or therapeutic use.