Target Protein: Rb(S807)
Modification Site: S807
Entrez Gene: 5925
Swiss Prot: P06400
Source: Synthetic peptide derived from human Rb(S807), around 800-850aa (phospho S807).
Purification: Purified by Protein A.
Storage Buffer: Aqueous buffered solution containing 1xTBS (pH7.4), 1%BSA, 40%Glycerol and 0.05% Sodium Azide.
Storage Condition: Store at -20°C for 12 months.
Background: Nuclear Marker.The protein encoded by this gene is a negative regulator of the cell cycle and was the first tumor suppressor gene found. The encoded protein also stabilizes constitutive heterochromatin to maintain the overall chromatin structure. The active, hypophosphorylated form of the protein binds transcription factor E2F1. Defects in this gene are a cause of childhood cancer retinoblastoma (RB), bladder cancer, and osteogenic sarcoma.
Cross Reactive Species:
For research use only. Not intended for diagnostic or therapeutic use.