bsm-52197R-FITC

DATASHEET

Host: Rabbit

Target Protein: Rb (Ser807)

Modification Site: S807

Clonality: Recombinant

Isotype: IgG

Entrez Gene: 5925

Swiss Prot: P06400

Source: KLH conjugated Synthesised phosphopeptide derived from human Rb around the phosphorylation site of Ser807

Purification: purified by Protein A.

Storage Buffer: Aqueous buffered solution containing 0.01M TBS (pH 7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.

Storage: Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.

Background:

Nuclear Marker.The protein encoded by this gene is a negative regulator of the cell cycle and was the first tumor suppressor gene found. The encoded protein also stabilizes constitutive heterochromatin to maintain the overall chromatin structure. The active, hypophosphorylated form of the protein binds transcription factor E2F1. Defects in this gene are a cause of childhood cancer retinoblastoma (RB), bladder cancer, and osteogenic sarcoma.

Conjugation: FITC

Excitation/ Emission: 494nm/518nm

Size: 100ul

Concentration: Lot Dependent

Applications: WB(1:500-2000)
IHC-F(1:50-200)
IF(1:50-200)
IHC-P(1:50-200)
ICC/IF(1:50-200)

Predicted Molecular Weight: 102 kDa

Cross Reactive Species: Human
Mouse
Rat

For research use only. Not intended for diagnostic or therapeutic use.