bsm-52211R-FITC

DATASHEET

Host: Rabbit

Target Protein: STAT3 (p-Y705)

Clonality: Recombinant

Isotype: IgG

Entrez Gene: 6774

Swiss Prot: P40763

Source: A synthesized peptide derived from human STAT3 around the phosphorylation site of Y705

Purification: purified by Protein A.

Storage Buffer: Aqueous buffered solution containing 0.01M TBS (pH 7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.

Storage: Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.

Background:

Signal transducer and transcription activator that mediates cellular responses to interleukins, KITLG/SCF and other growth factors. May mediate cellular responses to activated FGFR1, FGFR2, FGFR3 and FGFR4. Binds to the interleukin-6 (IL-6)-responsive elements identified in the promoters of various acute-phase protein genes. Activated by IL31 through IL31RA. Cytoplasmic STAT3 represses macroautophagy by inhibiting EIF2AK2/PKR activity. Plays an important role in host defense in methicillin-resistant S.aureus lung infection by regulating the expression of the antimicrobial lectin REG3G (By similarity).

Conjugation: FITC

Excitation/ Emission: 494nm/518nm

Size: 100ul

Concentration: 1mg/ml

Applications: WB(1:500-2000)
IHC-F(1:200-800)
IHC-P(1:200-800)
ICC/IF(1:100-200)
IF(1:200-800)
IP(1:50-100)

Predicted Molecular Weight: 85 kDa

Cross Reactive Species: Human
Mouse
Rat

For research use only. Not intended for diagnostic or therapeutic use.