bsm-52223R-FITC

DATASHEET

Host: Rabbit

Target Protein: Smad2

Clonality: Recombinant

Isotype: IgG

Entrez Gene: 4087

Swiss Prot: Q15796

Source: Recombinant human Smad2 protein, around N-terminal 1-200aa.

Purification: Purified by Protein A.

Storage Buffer: Aqueous buffered solution containing 0.01M TBS (pH 7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.

Storage: Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.

Background:

Receptor-regulated SMAD (R-SMAD) that is an intracellular signal transducer and transcriptional modulator activated by TGF-beta (transforming growth factor) and activin type 1 receptor kinases. Binds the TRE element in the promoter region of many genes that are regulated by TGF-beta and, on formation of the SMAD2/SMAD4 complex, activates transcription. May act as a tumor suppressor in colorectal carcinoma. Positively regulates PDPK1 kinase activity by stimulating its dissociation from the 14-3-3 protein YWHAQ which acts as a negative regulator.

Conjugation: FITC

Excitation/ Emission: 494nm/518nm

Size: 100µL

Concentration: Lot dependent

Applications: WB(1:300-5000)
IF(1:50-200)
Flow-Cyt(1ug/Test)

Cross Reactive Species: Human
Mouse
Rat

For research use only. Not intended for diagnostic or therapeutic use.