bsm-52280R-BF405

DATASHEET

Host: Rabbit

Target Protein: MAP2K1/2

Specificity: The antibody will detect both MAP2K1 and MAP2K2

Clonality: Monoclonal

Isotype: IgG

Entrez Gene: 5604; 5605

Swiss Prot: Q02750; P36507

Source: Human MAP2K1 + MAP2K2 aa 1 to the C-terminus

Purification: Purified by Protein A.

Storage Buffer: Aqueous buffered solution containing 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.

Storage: Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.

Background:

A family of protein kinases located upstream of the MAP kinases and responsible for their activation has been identified. The prototype member of this family, designated MAP kinase kinase, or MEK-1, specifically phosphorylates the MAP kinase regulatory threonine and tyrosine residues present in the Thr-Glu-Tyr motif of ERK. A second MEK family member, MEK-2, resembles MEK-1 in its substrate specificity. MEK-3 (or MKK-3) functions to activate p38 MAP kinase, and MEK-4 (also called SEK1 or MKK-4) activates both p38 and JNK MAP kinases. MEK-5 appears to specifically phosphorylate ERK5, whereas MEK-6 phosphorylates p38 and p38b. MEK-7 (or MKK-7) phosphorylates and activates the JNK signal transduction pathway.

Conjugation: AbBy Fluor-405

Excitation/ Emission: 401nm/421nm

Size: 100µL

Concentration: 1mg/ml

Applications: WB(1:300-5000)
IF(1:100-500)

Predicted Molecular Weight: 44

Cross Reactive Species: Human
Mouse
Rat
(Crucian carp (Carassius carassius))

For research use only. Not intended for diagnostic or therapeutic use.