bsm-52316R-Biotin [Conjugated Primary Antibody]
Bax Recombinant Antibody, Biotin Conjugated
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Host: Rabbit

Target Protein: Bax

Clonality: Recombinant

Isotype: IgG

Entrez Gene: 581

Swiss Prot: Q07812

Source: Recombinant human Bak between 20 to 150 amino acids

Purification: Purified by Protein A.

Storage Buffer: Aqueous buffered solution containing 0.01M TBS (pH 7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.

Storage: Store at -20°C for 12 months.

Background:

Accelerates programmed cell death by binding to, and antagonizing the apoptosis repressor BCL2 or its adenovirus homolog E1B 19k protein. Under stress conditions, undergoes a conformation change that causes translocation to the mitochondrion membrane, leading to the release of cytochrome c that then triggers apoptosis. Promotes activation of CASP3, and thereby apoptosis.

Conjugation: Biotin

Excitation/ Emission: N/A

Size: 100µL

Concentration: 1 mg/ml

Applications: WB(1:300-5000)
IHC-P(1:20-100)
IHC-F(1:200-400)

Predicted Molecular Weight: 21,15 kDa


Cross Reactive Species: Human
Mouse
Rat

For research use only. Not intended for diagnostic or therapeutic use.

PRODUCT SPECIFIC PUBLICATIONS
  • Shuang Huet al. MicroRNA-708 prevents ethanol-induced hepatic lipid accumulation and inflammatory reaction via direct targeting ZEB1. Life Sci. 2020 Oct 1;258:118147.Read more>>
  • Chenying Gao. et al. Inhibition of the Ras/ERK1/2 pathway contributes to the protective effect of ginsenoside Re against intimal hyperplasia. 2021 May 2Read more>>
  • Wang, Sanchun. et al. Pseudoginsengenin DQ exerts antitumour activity against hypopharyngeal cancer cells by targeting the HIF-1-GLUT1 pathway. Cancer Cell Int. 2021 Dec;21(1):1-12Read more>>
  • Xiaojing Zhang. et al. A new discovery: Total Bupleurum saponin extracts can inhibit the proliferation and induce apoptosis of colon cancer cells by regulating the PI3K/Akt/mTOR pathway. J Ethnopharmacol. 2022 Jan;283:114742Read more>>
  • Yanji Zhu. et al. P2X7R antagonist protects against renal injury in mice with adriamycin nephropathy. Exp Ther Med. 2022 Feb;23(2):1-8Read more>>
  • Chao Wang. et al. Inhibition of monoacylglycerol lipase restrains proliferation, migration, invasion, tumor growth and induces apoptosis in cervical cancer. 2021 Dec 07Read more>>
  • Zhuohong Li. et al. Anti-inflammatory and anti-apoptotic effects of Shaoyao decoction on X-ray radiation-induced enteritis of C57BL/6 mice. J Ethnopharmacol. 2022 Mar;:115158Read more>>
  • Yu-Sheng Shi. et al. Pteris laeta Wall. and Its New Phytochemical, Pterosinsade A, Promote Hippocampal Neurogenesis via Activating the Wnt Signaling Pathway. J AGR FOOD CHEM. 2023;XXXX(XXX):XXX-XXXRead more>>
  • Miao Song. et al. Mitophagy alleviates AIF-mediated spleen apoptosis induced by AlCl3 through Parkin stabilization in mice. FOOD CHEM TOXICOL. 2023 Jun;176:113762Read more>>
  • Fangji Zhou. et al. Mono-(2-ethylhexyl) Phthalate (MEHP)-Induced Telomere Structure and Function Disorder Mediates Cell Cycle Dysregulation and Apoptosis via c-Myc and Its Upstream Transcription Factors in a Mouse Spermatogonia-Derived (GC-1) Cell Line. TOXICS. 2023 May;11(5):448Read more>>
  • Gan Rao. et al. Arsenic and polystyrene-nano plastics co-exposure induced testicular toxicity: Triggers oxidative stress and promotes apoptosis and inflammation in mice. ENVIRON TOXICOL. 2023 SepRead more>>
  • Qifeng Shi. et al. PLC-CN-NFAT1 signaling-mediated A and IL-1 crosstalk synergistically promotes hippocampal neuronal damage. INT IMMUNOPHARMACOL. 2024 Jun;134:112259Read more>>
  • Xincheng Huang. et al. The use of matrine to inhibit osteosarcoma cell proliferation via the regulation of the MAPK/ERK signaling pathway.. FRONT ONCOL. 2024 Aug;14:1338811-1338811Read more>>
VALIDATION IMAGES