bsm-52566R
[Primary Antibody]
Caspase-9 (1D7) Monoclonal Antibody
DATASHEET
Host: Rabbit
Target Protein: Caspase-9
Clonality: Monoclonal
Isotype: IgG
Swiss Prot: P55211
Source: Human Caspase-9 aa 200-350
Purification: Purified by Protein A.
Storage Buffer: 0.01M TBS(pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.
Storage: Shipped at 4C. Store at -20C for one year. Avoid repeated freeze/thaw cycles.
Background:
Involved in the activation cascade of caspases responsible for apoptosis execution. Binding of caspase-9 to Apaf-1 leads to activation of the protease which then cleaves and activates caspase-3. Promotes DNA damage-induced apoptosis in a ABL1/c-Abl-dependent manner. Proteolytically cleaves poly(ADP-ribose) polymerase (PARP). Isoform 2 lacks activity is an dominant-negative inhibitor of caspase-9.
Size: 100ul
Concentration: 1ug/ul
Cross Reactive Species:
Human
Mouse
For research use only. Not intended for diagnostic or therapeutic use.
PRODUCT SPECIFIC PUBLICATIONS
- Qing Jin. et al. 125 I seeds irradiation inhibits tumor growth and induces apoptosis by Ki-67, P21, survivin, livin and caspase-9 expression in lung carcinoma xenografts. Radiat Oncol. 2020 Dec;15(1):1-1Read more>>
- Gan Rao. et al. Arsenic and polystyrene-nano plastics co-exposure induced testicular toxicity: Triggers oxidative stress and promotes apoptosis and inflammation in mice. ENVIRON TOXICOL. 2023 SepRead more>>
VALIDATION IMAGES
Lane 1: Jurkat Cells; Lane 2: Hela Cells; Lane 3: C2C12 Cells; Probed with Caspase-9 (1D7) Monoclonal Antibody (bsm-52566R) at 1:1000 overnight at 4°C followed by a conjugated secondary antibody for 60 minutes at 37°C.