DATASHEET
Host:
Rabbit
Target Protein:
Stromal interaction molecule 1
Clonality:
Monoclonal
Isotype:
IgG
Entrez Gene:
6786
Swiss Prot:
Q13586
Source:
Human Stromal interaction molecule 1 between 1-600 amino acids
Purification:
Purified by Protein A.
Storage Buffer:
0.01M TBS(pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.
Storage:
Store at -20°C for 12 months.
Background:
Plays a role in mediating store-operated Ca(2+) entry (SOCE), a Ca(2+) influx following depletion of intracellular Ca(2+) stores. Acts as Ca(2+) sensor in the endoplasmic reticulum via its EF-hand domain. Upon Ca(2+) depletion, translocates from the endoplasmic reticulum to the plasma membrane where it activates the Ca(2+) release-activated Ca(2+) (CRAC) channel subunit, TMEM142A/ORAI1.
VALIDATION IMAGES
Lane 1: K562 Cells; Lane 2:HepG2 Cells; Probed with Stromal interaction molecule 1 (7C4) Monoclonal Antibody (bsm-52677R) at 1:1000 overnight at 4°C followed by a conjugated secondary antibody for 60 minutes at 37°C.
Paraformaldehyde-fixed and paraffin-embedded Human spleen tissue incubated with Stromal interaction molecule 1 (7C4) Monoclonal Antibody (bsm-52677R) at 1:100, overnight at 4°C, followed by a conjugated secondary antibody and DAB staining. Counterstained with hematoxylin.
Paraformaldehyde-fixed and paraffin-embedded Mouse testis tissue incubated with Stromal interaction molecule 1 (7C4) Monoclonal Antibody (bsm-52677R) at 1:100, overnight at 4°C, followed by a conjugated secondary antibody and DAB staining. Counterstained with hematoxylin.