bsm-52793R-BF405

DATASHEET

Host: Rabbit

Target Protein: TFRC

Clonality: Recombinant

Isotype: IgG

Entrez Gene: P02786

Swiss Prot: P02786

Source: Human Transferrin Receptor between 100 to 450 amino acids

Purification: Purified by Protein A.

Storage Buffer: Aqueous buffered solution containing 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.

Storage: Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.

Background:

Cellular uptake of iron occurs via receptor-mediated endocytosis of ligand-occupied transferrin receptor into specialized endosomes. Endosomal acidification leads to iron release. The apotransferrin-receptor complex is then recycled to the cell surface with a return to neutral pH and the concomitant loss of affinity of apotransferrin for its receptor. Transferrin receptor is necessary for development of erythrocytes and the nervous system (By similarity). A second ligand, the heditary hemochromatosis protein HFE, competes for binding with transferrin for an overlapping C-terminal binding site.

Conjugation: AbBy Fluor-405

Excitation/ Emission: 401nm/421nm

Size: 100µL

Concentration: Lot dependent

Applications: WB(1:300-5000)
Flow-Cyt(1:20-100)
ICC/IF(1:50-100)

Cross Reactive Species: Human
Rat

Predicted Cross Reactive Species: Mouse

For research use only. Not intended for diagnostic or therapeutic use.