DATASHEET
Host:
Rabbit
Target Protein:
MMP13
Clonality:
Recombinant
Isotype:
IgG
Entrez Gene:
4322
Swiss Prot:
P45452
Source:
N terminus human MMP13
Purification:
Purified by Protein A.
Storage Buffer:
Aqueous buffered solution containing 0.01M TBS (pH 7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.
Storage:
Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.
Background:
Plays a role in the degradation of extracellular matrix proteins including fibrillar collagen, fibronectin, TNC and ACAN. Cleaves triple helical collagens, including type I, type II and type III collagen, but has the highest activity with soluble type II collagen. Can also degrade collagen type IV, type XIV and type X. May also function by activating or degrading key regulatory proteins, such as TGFB1 and CTGF. Plays a role in wound healing, tissue remodeling, cartilage degradation, bone development, bone mineralization and ossification. Required for normal embryonic bone development and ossification. Plays a role in the healing of bone fractures via endochondral ossification. Plays a role in wound healing, probably by a mechanism that involves proteolytic activation of TGFB1 and degradation of CTGF. Plays a role in keratinocyte migration during wound healing. May play a role in cell migration and in tumor cell invasion.
Conjugation:
Cy7
Excitation/ Emission:
743nm/767nm
Size:
100µL
Concentration:
Lot dependent
Applications:
WB(WB(1:500-2000))
Human
Predicted Cross Reactive Species:
Mouse
For research use only. Not intended for diagnostic or therapeutic use.