DATASHEET
Host:
Rabbit
Target Protein:
Podoplanin
Clonality:
Monoclonal
Isotype:
IgG
Entrez Gene:
10630
Swiss Prot:
Q86YL7
Source:
Human Podoplanin aa 1-100
Purification:
Purified by Protein A.
Storage Buffer:
0.01M TBS(pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.
Storage:
Store at -20°C for 12 months.
Background:
May be involved in cell migration and/or actin cytoskeleton organization. When expressed in keratinocytes, induces changes in cell morphology with transfected cells showing an elongated shape, numerous membrane protrusions, major reorganization of the actin cytoskeleton, increased motility and decreased cell adhesion. Required for normal lung cell proliferation and alveolus formation at birth. Induces platelet aggregation. Does not have any effect on folic acid or amino acid transport. Does not function as a water channel or as a regulator of aquaporin-type water channels.
VALIDATION IMAGES
Lane 1: Human Lung; Probed with Podoplanin (3C3) Monoclonal Antibody (bsm-52936R) at 1:500 overnight at 4°C followed by a conjugated secondary antibody for 60 minutes at 37°C.
Paraformaldehyde-fixed and paraffin-embedded Human Colon Cancer tissue incubated with Podoplanin (3C3) Monoclonal Antibody (bsm-52936R) at 1:100, overnight at 4°C, followed by a conjugated secondary antibody and DAB staining. Counterstained with hematoxylin.
Paraformaldehyde-fixed and paraffin-embedded Human Lung tissue incubated with Podoplanin (3C3) Monoclonal Antibody (bsm-52936R) at 1:100, overnight at 4°C, followed by a conjugated secondary antibody and DAB staining. Counterstained with hematoxylin.