bsm-52944R-RBITC

DATASHEET

Host: Rabbit

Target Protein: A2M

Clonality: Recombinant

Isotype: IgG

Entrez Gene: 2

Swiss Prot: P01023

Source: A synthesized peptide derived from human alpha 2 Macroglobulin

Purification: purified by Protein A.

Storage Buffer: Aqueous buffered solution containing 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.

Storage: Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.

Background:

Is able to inhibit all four classes of proteinases by a unique 'trapping' mechanism. This protein has a peptide stretch, called the 'bait region' which contains specific cleavage sites for different proteinases. When a proteinase cleaves the bait region, a conformational change is induced in the protein which traps the proteinase. The entrapped enzyme remains active against low molecular weight substrates (activity against high molecular weight substrates is greatly reduced). Following cleavage in the bait region a thioester bond is hydrolyzed and mediates the covalent binding of the protein to the proteinase.

Conjugation: RBITC

Excitation/ Emission: 570nm/595nm

Size: 100ul

Concentration: Lot Dependent

Applications: WB(1:1000-2000)
IHC-F(1:100-500)
IHC-P(1:100-500)
IF(1:100-500)

Predicted Molecular Weight: 160 kDa

Cross Reactive Species: Human

For research use only. Not intended for diagnostic or therapeutic use.