DATASHEET
Host:
Rabbit
Target Protein:
NeuroD1
Immunogen Range:
1-50/356
Clonality:
Recombinant
Isotype:
IgG
Entrez Gene:
4760
Swiss Prot:
Q13562
Source:
N terminal human NeuroD1
Purification:
Purified by Protein A.
Storage Buffer:
Aqueous buffered solution containing 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.
Storage:
Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.
Background:
Acts as a transcriptional activator: mediates transcriptional activation by binding to E box-containing promoter consensus core sequences 5'-CANNTG-3'. Associates with the p300/CBP transcription coactivator complex to stimulate transcription of the secretin gene as well as the gene encoding the cyclin-dependent kinase inhibitor CDKN1A. Contributes to the regulation of several cell differentiation pathways, like those that promote the formation of early retinal ganglion cells, inner ear sensory neurons, granule cells forming either the cerebellum or the dentate gyrus cell layer of the hippocampus, endocrine islet cells of the pancreas and enteroendocrine cells of the small intestine. Together with PAX6 or SIX3, is required for the regulation of amacrine cell fate specification. Also required for dendrite morphogenesis and maintenance in the cerebellar cortex. Associates with chromatin to enhancer regulatory elements in genes encoding key transcriptional regulators of neurogenesis.
Conjugation:
AbBy Fluor-680
Excitation/ Emission:
679nm/702nm
Size:
100µL
Concentration:
Lot dependent
Applications:
WB(WB(1:500-2000))
45
Human
Rat
For research use only. Not intended for diagnostic or therapeutic use.