bsm-53011M [Primary Antibody]
SirT1 (9C9) Monoclonal Antibody
www.biossusa.com
[email protected]
800.501.7654 [DOMESTIC]
+1.781.569.5821 [INTERNATIONAL]
DATASHEET

Host: Mouse

Target Protein: SirT1

Clonality: Monoclonal

Isotype: IgG1

Entrez Gene: 23411

Swiss Prot: Q96EB6

Source: Monoclonal antibody raised in mouse against human SirT1 (NAD-dependent deacetylase sirtuin-1) using a synthetic peptide

Purification: Protein G purified monoclonal antibody in PBS containing 0.05% azide and 0.05% ProClin 300

Storage Buffer: 0.01M TBS(pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.

Storage: Store at -20°C for 12 months.

Background:

This gene encodes a member of the sirtuin family of proteins, homologs to the yeast Sir2 protein. Members of the sirtuin family are characterized by a sirtuin core domain and grouped into four classes. The functions of human sirtuins have not yet been determined; however, yeast sirtuin proteins are known to regulate epigenetic gene silencing and suppress recombination of rDNA. Studies suggest that the human sirtuins may function as intracellular regulatory proteins with mono-ADP-ribosyltransferase activity. The protein encoded by this gene is included in class I of the sirtuin family. Alternative splicing results in multiple transcript variants. [provided by RefSeq, Dec 2008]

Size: 50ug

Concentration: 0.7ug/ul

Cross Reactive Species: Human

For research use only. Not intended for diagnostic or therapeutic use.

VALIDATION IMAGES

Western blot was performed using nuclear extracts from HeLa cells (20 μg) and SirT1 (9C9) Monoclonal Antibody (bsm-53011M) diluted 1:500 in TBS-Tween containing 5% skimmed milk. The molecular weight marker (in kDa) is shown on the left, the position of the protein of interest is shown on the right.