bsm-54023R [Primary Antibody]
LXR alpha Recombinant Antibody
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Host: Rabbit

Target Protein: LXR alpha

Immunogen Range: 60-110/447


Clonality: Monoclonal

Isotype: IgG

Entrez Gene: 10062

Swiss Prot: Q13133

Source: C terminal Human LXR alpha

Purification: Purified by Protein A.

Storage Buffer: 0.01M TBS(pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.

Storage: Shipped at 4C. Store at -20C for one year. Avoid repeated freeze/thaw cycles.

Background:

Nuclear receptor that exhibits a ligand-dependent transcriptional activation activity. Interaction with retinoic acid receptor (RXR) shifts RXR from its role as a silent DNA-binding partner to an active ligand-binding subunit in mediating retinoid responses through target genes defined by LXRES. LXRES are DR4-type response elements characterized by direct repeats of two similar hexanucleotide half-sites spaced by four nucleotides. Plays an important role in the regulation of cholesterol homeostasis, regulating cholesterol uptake through MYLIP-dependent ubiquitination of LDLR, VLDLR and LRP8. Interplays functionally with RORA for the regulation of genes involved in liver metabolism.

Size: 100µL

Concentration: Lot Dependent

Cross Reactive Species: Human
Mouse
Rat

For research use only. Not intended for diagnostic or therapeutic use.

PRODUCT SPECIFIC PUBLICATIONS
  • Yueqi Cui. et al. The activation of liver X receptors in Madin-Darby bovine kidney cells and mice restricts infection by bovine viral diarrhea virus. VET MICROBIOL. 2023 Dec;:109948Read more>>
VALIDATION IMAGES

25 ug total protein per lane of various lysates (see on figure) probed with LXR alpha monoclonal antibody, unconjugated (bsm-54023R) at 1:1000 dilution and 4°C overnight incubation. Followed by conjugated secondary antibody incubation at r.t. for 60 min.