DATASHEET
Host:
Rabbit
Target Protein:
DOPA Decarboxylase
Clonality:
Monoclonal
Isotype:
IgG
Entrez Gene:
1644
Swiss Prot:
P20711
Source:
N terminal human DOPA Decarboxylase
Purification:
Purified by Protein A.
Storage Buffer:
0.01M TBS(pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.
Storage:
Store at 4°C for up to 2 weeks. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.
Background:
The encoded protein catalyzes the decarboxylation of L-3,4-dihydroxyphenylalanine (DOPA) to dopamine, L-5-hydroxytryptophan to serotonin and L-tryptophan to tryptamine. Defects in this gene are the cause of aromatic L-amino-acid decarboxylase deficiency (AADCD). AADCD deficiency is an inborn error in neurotransmitter metabolism that leads to combined serotonin and catecholamine deficiency. Multiple alternatively spliced transcript variants encoding different isoforms have been identified for this gene.
VALIDATION IMAGES
Paraformaldehyde-fixed and paraffin-embedded Human Kidney tissue incubated DOPA Decarboxylase (2C12) Monoclonal Antibody (bsm-54061R) at 1:100, overnight at 4°C, followed by a conjugated secondary antibody and DAB staining. Counterstained with hematoxylin.
Paraformaldehyde-fixed and paraffin-embedded Human Liver tissue incubated DOPA Decarboxylase (2C12) Monoclonal Antibody (bsm-54061R) at 1:100, overnight at 4°C, followed by a conjugated secondary antibody and DAB staining. Counterstained with hematoxylin.