bsm-54093R [Primary Antibody]
PRKD1 (10C1) Monoclonal Antibody
www.biossusa.com
[email protected]
800.501.7654 [DOMESTIC]
+1.781.569.5821 [INTERNATIONAL]
DATASHEET

Host: Rabbit

Target Protein: PRKD1

Clonality: Monoclonal

Isotype: IgG

Entrez Gene: 5587

Swiss Prot: Q15139

Source: Human PKC mu aa 500-650

Purification: Purified by Protein A.

Storage Buffer: 0.01M TBS(pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.

Storage: Store at 4°C for up to 2 weeks. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Background:

Converts transient diacylglycerol (DAG) signals into prolonged physiological effects, downstream of PKC. In epithelial cells, is required for transducing flagellin-stimulated inflammatory responses by binding and phosphorylating TLR5, which contributes to MAPK14/p38 activation and production of inflammatory cytokines. May play a role in inflammatory response by mediating activation of NF-kappa-B. May be involved in pain transmission by directly modulating TRPV1 receptor. Plays a role in activated KRAS-mediated stabilization of ZNF304 in colorectal cancer (CRC) cells. Regulates nuclear translocation of transcription factor TFEB in macrophages upon live S.enterica infection.

Size: 100ul

Concentration: 1ug/ul

Predicted Molecular Weight: 102


Cross Reactive Species: Human
Mouse
Rat

For research use only. Not intended for diagnostic or therapeutic use.

VALIDATION IMAGES

Lane 1: Hela Cells; Lane 2: Mouse Kidney; Lane 3: PC-12 Cells; Probed with PRKD1 (10C1) Monoclonal Antibody (bsm-54093R) at 1:1000 overnight at 4°C followed by a conjugated secondary antibody for 60 minutes at 37°C.