bsm-54119R [Primary Antibody]
PPARG coactivator 1 beta (6H5) Monoclonal Antibody
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Host: Rabbit

Target Protein: PPARGC1B

Clonality: Monoclonal

Isotype: IgG

Entrez Gene: 133522

Swiss Prot: Q86YN6

Source: Recombinant protein within C-terminal human PGC1 beta

Purification: Purified by Protein A.

Storage Buffer: 0.01M TBS(pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.

Storage: Store at 4°C for up to 2 weeks. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Background:

Plays a role of stimulator of transcription factors and nuclear receptors activities. Activates transcriptional activity of estrogen receptor alpha, nuclear respiratory factor 1 (NRF1) and glucocorticoid receptor in the presence of glucocorticoids. May play a role in constitutive non-adrenergic-mediated mitochondrial biogenesis as suggested by increased basal oxygen consumption and mitochondrial number when overexpressed. May be involved in fat oxidation and non-oxidative glucose metabolism and in the regulation of energy expenditure. Induces the expression of PERM1 in the skeletal muscle in an ESRRA-dependent manner.

Size: 100µL

Concentration: 1ug/ul

Predicted Molecular Weight: 113


Cross Reactive Species: Human
Rat

For research use only. Not intended for diagnostic or therapeutic use.

VALIDATION IMAGES

Lane 1: Rat Spleen; Probed with PPARG coactivator 1 beta (6H5) Monoclonal Antibody (bsm-54119R) at 1:1000 overnight at 4°C followed by a conjugated secondary antibody for 60 minutes at 37°C.


Flow cytometric analysis of HL-60 cells with PPARG coactivator 1 beta (6H5) Monoclonal Antibody (bsm-54119R) at 1:100 dilution (red) compared with an unlabeled control (cells without incubation with primary antibody; black).