bsm-54122R [Primary Antibody]
TMEM173 (1B8) Monoclonal Antibody
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Host: Rabbit

Target Protein: TMEM173

Clonality: Monoclonal

Isotype: IgG

Entrez Gene: 340061

Swiss Prot: Q86WV6

Source: Recombinant protein within human TMEM173 aa 200 to the C-terminus

Purification: Purified by Protein A.

Storage Buffer: 0.01M TBS(pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.

Storage: Store at 4°C for up to 2 weeks. For long term storage, store at -20°C in small aliquots to prevent freeze-thaw cycles.

Background:

Facilitator of innate immune signaling that promotes the production of type I interferon (IFN-alpha and IFN-beta). Innate immune response is triggered in response to non-CpG double-stranded DNA from viruses and bacteria delivered to the cytoplasm. Able to activate both NF-kappa-B and IRF3 transcription pathways to induce expression of type I interferon and exert a potent anti-viral state following expression. May be involved in translocon function, the translocon possibly being able to influence the induction of type I interferons. May be involved in transduction of apoptotic signals via its association with the major histocompatibility complex class II (MHC-II). Mediates death signaling via activation of the extracellular signal-regulated kinase (ERK) pathway.

Size: 100ul

Concentration: 1ug/ul

Predicted Molecular Weight: 37


Cross Reactive Species: Human

For research use only. Not intended for diagnostic or therapeutic use.

VALIDATION IMAGES

Lane 1: U937 Cells; Lane 2: 293 Cells; Probed with TMEM173 (1B8) Monoclonal Antibody (bsm-54122R) at 1:1000 overnight at 4°C followed by a conjugated secondary antibody for 60 minutes at 37°C.


Flow cytometric analysis of THP-1 cells with TMEM173 (1B8) Monoclonal Antibody (bsm-54122R) at 1:100 dilution (red) compared with an unlabeled control (cells without incubation with primary antibody; black).