DATASHEET
Host:
Rabbit
Target Protein:
Growth hormone receptor
Clonality:
Monoclonal
Isotype:
IgG
Entrez Gene:
2690
Swiss Prot:
P10912
Source:
Synthetic peptide within human Growth hormone receptor aa 500-630
Purification:
purified by Protein A.
Storage Buffer:
0.01M TBS(pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.
Storage:
Shipped at 4℃. Store at -20°C for one year. Avoid repeated freeze/thaw cycles.
Background:
GHR is a member of the type I cytokine receptor family, which is a transmembrane receptor for growth hormone. It is a receptor for pituitary gland growth hormone involved in regulating postnatal body growth. Binding of growth hormone to the receptor leads to receptor dimerization and the activation of an intra- and intercellular signal transduction pathway leading to growth. On ligand binding, couples to the JAK2/STAT5 pathway. The soluble form (GHBP) acts as a reservoir of growth hormone in plasma and may be a modulator/inhibitor of GH signaling. Isoform 2 up-regulates the production of GHBP and acts as a negative inhibitor of GH signaling. Mutations in this gene have been associated with Laron syndrome, also known as the growth hormone insensitivity syndrome (GHIS), a disorder characterized by short stature. In humans and rabbits, but not rodents, growth hormone binding protein (GHBP) is generated by proteolytic cleavage of the extracellular ligand-binding domain from the mature growth hormone receptor protein. Multiple alternatively spliced transcript variants have been found for this gene
Size:
100ul
Concentration:
Lot Dependent
Applications:
WB(1:300-5000)
IF(IHC-P)(1:50-200)
IF(ICC)(1:50-200)
FCM(10ul/10^6 cells in 100ul)
IHC-P(1:50-200)
Human
Mouse
Predicted Cross Reactive Species:
Rat
For research use only. Not intended for diagnostic or therapeutic use.