bsm-54277R-BF594

DATASHEET

Host: Rabbit

Target Protein: Alpha Synuclein

Clonality: Recombinant

Isotype: IgG

Entrez Gene: 6622

Swiss Prot: P37840

Source: Recombinant full length Human protein

Purification: Purified by Protein A.

Storage Buffer: Aqueous buffered solution containing 0.01M TBS (pH7.4) with 1% BSA, 0.02% Proclin300 and 50% Glycerol.

Storage: Store at -20°C. Aliquot into multiple vials to avoid repeated freeze-thaw cycles.

Background:

Neuronal protein that plays several roles in synaptic activity such as regulation of synaptic vesicle trafficking and subsequent neurotransmitter release. Participates as a monomer in synaptic vesicle exocytosis by enhancing vesicle priming, fusion and dilation of exocytotic fusion pores. Mechanistically, acts by increasing local Ca2+ release from microdomains which is essential for the enhancement of ATP-induced exocytosis. Acts also as a molecular chaperone in its multimeric membrane-bound state, assisting in the folding of synaptic fusion components called SNAREs (Soluble NSF Attachment Protein REceptors) at presynaptic plasma membrane in conjunction with cysteine string protein-alpha/DNAJC5. This chaperone activity is important to sustain normal SNARE-complex assembly during aging. Plays also a role in the regulation of the dopamine neurotransmission by associating with the dopamine transporter (DAT1) and thereby modulating its activity

Conjugation: AbBy Fluor-594

Excitation/ Emission: 590nm/617nm

Size: 100µL

Concentration: 1mg/ml

Applications: WB(WB(1:1000-2000))
FCM(FCM(1:50-100))
IF(IHC-P)(IF(IHC-P)(1:200-800))
IF(ICC)(IF(ICC)(1:50-200))

Predicted Molecular Weight: 16

Cross Reactive Species: Human
Rat

For research use only. Not intended for diagnostic or therapeutic use.